14-3-3 phosphoprotein interaction networks – does isoform diversity present functional interaction specification?
نویسندگان
چکیده
منابع مشابه
14-3-3 phosphoprotein interaction networks – does isoform diversity present functional interaction specification?
The 14-3-3 proteins have emerged as major phosphoprotein interaction proteins and thereby constitute a key node in the Arabidopsis Interactome Map, a node through which a large number of important signals pass. Throughout their history of discovery and description, the 14-3-3s have been described as protein families and there has been some evidence that the different 14-3-3 family members withi...
متن کاملInteraction of phosphorylated tryptophan hydroxylase with 14-3-3 proteins.
Rabbit brain tryptophan hydroxylase (TPH) has been expressed in insect cells (Spodoptera frugiperda) as a histidine-tagged enzyme. The specific activity of the purified fusion enzyme is 80 nmol of 5-hydroxytryptophan/min/mg. Multifunctional regulatory 14-3-3 proteins were purified from fresh bovine brain. Phosphorylation and 14-3-3 proteins play important roles in the regulation of TPH activity...
متن کاملInteraction between Rho GTPases and 14-3-3 Proteins
The Rho GTPase family accounts for as many as 20 members. Among them, the archetypes RhoA, Rac1, and Cdc42 have been the most well-characterized. Like all members of the small GTPases superfamily, Rho proteins act as molecular switches to control cellular processes by cycling between active, GTP-bound and inactive, GDP-bound states. The 14-3-3 family proteins comprise seven isoforms. They exist...
متن کاملSpecificity of 14-3-3 isoform dimer interactions and phosphorylation.
Proteins that interact with 14-3-3 isoforms are involved in regulation of the cell cycle, intracellular trafficking/targeting, signal transduction, cytoskeletal structure and transcription. Recent novel roles for 14-3-3 isoforms include nuclear trafficking the direct interaction with cruciform DNA and with a number of receptors, small G-proteins and their regulators. Recent findings also show t...
متن کاملExposed loop domains of complexed 14-3-3 proteins contribute to structural diversity and functional specificity.
The 14-3-3 family of proteins functions through protein:phosphoprotein interactions, the nature of which has been elucidated using x-ray crystallography. However, some key structural features in nonconserved regions have yet to be fully resolved, leaving open questions regarding the functional selectivity of 14-3-3 family members for diverse clients. In an effort to study surface accessible str...
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ژورنال
عنوان ژورنال: Frontiers in Plant Science
سال: 2012
ISSN: 1664-462X
DOI: 10.3389/fpls.2012.00190